次の方法で、順番に試していくと良い

「設定」で、ミュートになっていないかを確認する

PipeWire を再起動

$ systemctl --user restart pipewire

または

$ ps aux | grep　pipewire
KanraKa+  340222  0.0  0.0 261152 10888 ?        S<sl 01:07   0:00　/usr/bin/pipewire
$ kill -HUP 340222

Pipewire 用の PulseAudio をインストール

$ sudo dnf install pipewire-pulseaudio --allowerasing

PulseAudio を起動 ＆設定

$ systemctl --user start pipewire-pulse.service 
$ systemctl --user enable pipewire-pulse.service
$ systemctl --user status pipewire-pulse.service
● pipewire-pulse.service - PipeWire PulseAudio
           Loaded: loaded (/usr/lib/systemd/user/pipewire-pulse.service; enabled; vendor preset: disabled)
           Active: active (running) since Thu 2022-01-13 11:03:57 JST; 3h 27min ago
TriggeredBy: ● pipewire-pulse.socket
     Main PID: 2843 (pipewire-pulse)
           Tasks: 2 (limit: 154562)
       Memory: 20.5M
              CPU: 4min 51.350s
        CGroup: /user.slice/user-1000.slice/user@1000.service/session.slice/pipewire-pulse.service
                     └─2843 /usr/bin/pipewire-pulse
$ 

駄目なら再起動

$ sudo systemctl reboot